Effect of Momordicacharantia L. (Bitter gourd) Methanol Leaves extract on Hematological parameters, Lipid Profile and Antioxidant Vitamins in Alloxan Induces Diabetic Albino Rats

Diabetes mellitus is a met¬abolic disorders characterized by persistent hyper¬glycemia and disturbances in the metabolism of fuel molecules as a result of absolute defi¬ciency in insulin secretion or/and insulin action. MomordicacharantiaL. popularly known as bitter gourd or balsam pear belongs to a family Cucurbitaceae. It is one of the important vegetablesthatenrich in nutrition and medicinal properties. The bitter gourd vegetable is widely grown in Africa because of its medicinal application and also for the ornamental value. In this study alloxan induced diabetic rats were used, which were treated with different concentration (100, 200 and 300) of bitter gourd leaves extract. Theserum glucose concentrationwas showed significant decreases in the entire treated group regime (100, 200 and 300mg/kgMCMLE) when compared with the diabetic control group. The study alsoshowed a significant increase in PCV and MCHC haematological parametersanda significant decrease in lipid profile and antioxidant vitamins when compared with the diabetic control groupthis signified that the plant extract may contains numerous pharmacologically active that could be responsible for the observed glucose lowering potentials and strong antioxidant activities.